This year’s virtual meeting included a number of clinical trial presentations focused on these cancers. "When making these decisions, it is important to focus energy and resources on proven therapies that can prolong life.". Of those whose disease responded to initial systemic therapy, or stayed stable, 256 women agreed to be randomised to either continue with systemic therapy or to receive surgery and radiation (local therapy) and then continue on with systemic treatment. The San Antonio Breast Cancer Symposium 2020 (SABCS 2020) is one of the most important breast cancer conferences in the world and brings together the world’s leading breast cancer researchers, including those from Breast Cancer Trials. Clinical trials are research studies in which people agree to try new therapies (under careful supervision) in order to help doctors identify the best treatments with the fewest side effects. Patients must have received at least two prior therapies before receiving the drug. Research News. She stressed that ongoing and future studies will likely reveal markers that will help identify the right population of patients for AKT inhibition. At the 2020 ESMO meeting, researchers reported a 16 percent increase in pathological complete response (no invasive cancer at time of surgery) in patients receiving the checkpoint inhibitor therapy plus chemotherapy compared to those who received the placebo. We searched for primary research and reviews published in English between Jan 1, 1980, and April 22, 2020. In discussing the results and the future of targeted inhibition of the AKT pathway, given inconsistent clinical trial results, Dr. Rebecca Dent of Singapore National Cancer Center noted that there is still much we don’t understand about the effects of targeting AKT, particularly in TNBC, a highly heterogeneous disease with a variety of molecular drivers. It found that there was no quality of life advantage in the group of women who received local therapy to the breast tumour. Clinical trials … Looking at emerging targeted agents for TNBC. The other 15 breast cancer‐selective trials or cohorts had enrollment restricted only to breast cancer or a particular breast cancer subtype. This is an important finding, since adding any kind of treatment can reduce a patient’s quality of life and functional status, in addition to the fact that many patients with early-stage breast cancer do not experience symptoms from their breast cancer. Home Blog ASCO Annual Meeting 2020: Early-Stage Breast Cancer Treatment Updates. SABCS has a new New site www.sabcsmeetingnews.org. With your continued support, we can make every U.S. breast cancer trial available on our clinical trial search platform and bring you the most relevant and trusted news and... Read more. 14/12/2020. While the study was not designed to make statistical comparisons between the chemotherapy groups, an added benefit of immunotherapy was seen across all chemotherapy regimens, providing additional support for the use of anti-PD-L1 immunotherapy for the treatment of mTNBC. Breast cancer can spread outside the mammary tissues and travel to other places of the body through blood and lymph vessels; when that occurs it is called metastatic or stage IV cancer. Conference Summaries. Michael and his wife share a common bond: both are breast cancer survivors. HER2. Mammograms are commonly used to screen for breast cancer. These studies help improve the overall standard of care. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. "Instead, we find that the adverse effects of surgery and radiation appear to balance out the gains in quality of life that were achieved with better control of the primary tumour.". It became clear that a clinical trial was needed to provide women and their doctors with good information. In E2108, 390 women with stage IV breast cancer were enrolled. IMpassion031 is a phase III trial in patients with early-stage TNBC testing the safety and effectiveness of the checkpoint inhibitor atezolizumab used in tandem with standard chemotherapy prior to surgery (called neoadjuvant therapy). Data on overall survival are expected to be reported in 2021. About one in every 20 women diagnosed with breast cancer in the United States each year present with cancer that has already spread beyond the breast to other organs (also called stage IV, advanced, metastatic, or distant breast cancer). Based on results from the phase II study published in The New England Journal of Medicine, SG was granted accelerated FDA approval in 2020 for advanced, refractory TNBC under the trade name Trodelvy©. Confirming findings from the phase II study, patients receiving SG had better progression-free survival FS) and overall survival. 2020 Sep;31(9):1223-1230. doi: 10.1016/j.annonc.2020.05.012. ASCO Annual Meeting 2020: Early-Stage Breast Cancer Treatment Updates . IPATunity 130 is a double-blind, placebo-controlled, randomized phase III study testing the combination of the targeted agent ipatasertib with paclitaxel in patients with locally advanced or mTNBC that harbor mutations in PIK3CA/AKT1/PTEN pathway. Checkpoint inhibitors work by blocking the immune suppression action of the PD-1/PD-L1 pathway, which is shown to be activated in immune cells in the microenvironment of some breast cancers allowing tumors to avoid detection by the immune system. 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