We used the Cochran Q test to examine heterogeneity among the included trials. The median duration of follow-up was 37.9 months.  GH, Lee Nonischemic cardiomyopathy is damage to the heart muscle that is not associated with interruptions to the heart's blood supply, as seen in cases of coronary artery disease. Clinical Topics: Arrhythmias and Clinical EP, Heart Failure and Cardiomyopathies, Noninvasive Imaging, Prevention, Implantable Devices, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Acute Heart Failure, Magnetic Resonance Imaging, Keywords: Arrhythmias, Cardiac, Cardiomyopathies, Cicatrix, Cost-Benefit Analysis, Death, Sudden, Cardiac, Defibrillators, Implantable, Diagnostic Imaging, Gadolinium, Heart Failure, Magnetic Resonance Imaging, Primary Prevention, Secondary Prevention, Stroke Volume. The following are key points to remember from this review article about the diagnosis and evaluation of dilated cardiomyopathy (DCM), divided into four parts: 1) evaluation of etiology, 2) assessment of remodeling, 3) evaluation for an implantable cardioverter-defibrillator (ICD), and 4) … The data became the back bone of the current American College of Cardiology/American Heart Association guidelines for ICD implantation in patients with NICM. Get free access to newly published articles. In this meta-analysis of 4 randomized clinical trials that included 1874 patients with nonischemic cardiomyopathy, use of primary prevention implantable cardioverter defibrillators reduced all-cause mortality by 25%. 1. 2017;2(6):685–688. DOI: 10.1161/CIR.0000000000000455 December 6, 2016 e581 CLINICAL STATEMENTS AND GUIDELINES treatment, the prognosis of HF Accessibility Statement, Figure 1. The frequent use of CRT likely contributed to the lower than projected mortality rate in both groups in the DANISH trial. Congenital Heart Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism, CardioSource Plus for Institutions and Practices, Nuclear Cardiology and Cardiac CT Meeting on Demand, Annual Scientific Session and Related Events, ACC Quality Improvement for Institutions Program, National Cardiovascular Data Registry (NCDR). Finally, the high use of CRT and guideline-directed medical therapy in the DANISH trial likely reduced their statistical power for showing a significant difference in the primary outcome, despite extending the follow-up period to more than 67 months. Main Outcomes and Measures  Reduction in Mortality From Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy Patients Is Dependent on the Presence of Left Ventricular Scar. CRT indicates cardiac resynchronization therapy; ICD, implantable cardioverter defibrillator. PubMed was searched from January 1, 2000, through October 31, 2016, for the terms. Conflicting data have emerged on the efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention of sudden cardiac death (primary prevention ICDs) in patients with nonischemic cardiomyopathy. The subjects of this study were 452 patients (mean age 53.4 years) referred for cardiac magnetic resonance (CMR) imaging who had a NICM, LV ejection fraction (LVEF) ≤35% (mean 25.2%), New York Heart Association class II or III, and no history of ventricular tachycardia/fibrillation. The search yielded 10 studies, of which only 1 met the inclusion criteria.  JP,  et al; Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. We found no evidence that time was a modifier of the relationship between use of an ICD and all-cause mortality (P = .53). We performed 2 sensitivity analyses. ATTRamyloidosis-transthyretin type 9. Introduction Sudden cardiac death (SCD) is a term used to signify an abrupt and unexpected cessation of cardiac activity leading to complete hemodynamic collapse and resulting in the death of the victim.  P.  Implantable cardioverter-defibrillator for non ischemic cardiomyopathy: an updated meta-analysis. 10 Several specific diseases of the heart muscle or … We searched PubMed using the following search terms: implantable defibrillator OR implantable cardioverter defibrillator AND non-ischemic cardiomyopathy. Our findings are consistent with the results of the DEFINITE1 and SCD-HeFT2 trials. improving cardiac function and reducing heart failure symptoms 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. ACEangiotensin-converting enzyme 4. Does use of primary prevention implantable cardioverter defibrillators improve survival among patients with nonischemic cardiomyopathy? Studies that included an ICD arm, a medical therapy arm, and other comparators were included if data on the ICD and medical therapy arms were reported separately. 1 Autopsy and clinical studies have shown that the presence of structural heart disease increases the risk of SCD, with coronary heart disease accounting for the majority of cases. Crawford is on the speaker's Nonischemic cardiomyopathy Symptoms, Causes, Prognosis, Expectancy, Treatment. ARaortic regurgitation 7. Epub 2019 Jan 3. Al-Khatib SM, Fonarow GC, Joglar JA, et al. Data Sources PubMed was searched from January 1, 2000, through October 31, 2016, for the terms implantable defibrillator OR implantable cardioverter defibrillator AND non-ischemic cardiomyopathy . to download free article PDFs, Conclusions and Relevance  All Rights Reserved. It typically affects young adults.  et al. The primary end point was all-cause mortality. More granular data on the mode of death from the DANISH trial would be important. Study supervision: Joglar, Bardy, Sanders. Study Selection   AE, DiMarco 99mTc-DPD99mTechnetium-3,3-diphosphono-1,2-propanodi-carboxylic acid 3. We will discuss the cardiomyopathies listed in the table on the left. CCSCanadian Cardiovascular Society 14. Dilated Cardiomyopathy : this is the most common type. These findings support professional guidelines that recommend the use of ICDs in such patients. Meaning  Ischemic and non-ischemic cardiomyopathy Wouter van Es, Hans van Heesewijk, Benno Rensing, Jan van der Heijden and Robin Smithuis Radiology and Cardiology department of the St. Antonius Hospital in Nieuwegein and the RESEARCH DESIGN … Pooling data from these trials showed a significant reduction in all-cause mortality with an ICD (hazard ratio, 0.75; 95% CI, 0.61-0.93; Primary prevention ICDs are efficacious at reducing all-cause mortality among patients with nonischemic cardiomyopathy. ARBangiotensin receptor blocker 8. Ischemic cardiomyopathy is a type of cardiomyopathy caused by a narrowing of the coronary arteries which supply blood to the heart.  S, Chest X-ray.  KL, Skiba • The most common causes of non-ischemic cardiomyopathy are viral infection (viral myocarditis), drug This search yielded 10 studies, of which only 1 (the DEFINITE trial) met our criteria (2 studies included CRT only, 1 compared ICD with amiodarone only, and 6 were substudies of the DEFINITE trial). Data Extraction and Synthesis  BiVADbiventricular assist device 11. Additional references were identified from bibliographies of pertinent articles and queries to experts in this field. GUIDELINES More Cardiomyopathies Considerations ↑ risk of perioperative hemodynamic compromise: CHF, dysrhythmias, emboli, myocardial ischemia Type, etiology & severity of cardiomyopathy… The Diagnosis and Evaluation of Dilated Cardiomyopathy. BPMBeats per minute 13. We showed a significant survival benefit of use of an ICD in patients with nonischemic cardiomyopathy. Real-world data on patients with nonischemic cardiomyopathy from the German Device Registry. Congestive Cardiomyopathy - Coding guidelines state that congestive cardiomyopathy, which can also be called "congestive dilated cardiomyopathy," should be reported with I42.0, Dilated cardiomyopathy… Prior studies have demonstrated that LVS identified by CMR imaging is associated with malignant ventricular arrhythmias and appropriate ICD therapies. The PRISMA guidelines were used to abstract data and assess data quality and validity. Eur Heart J 2018;Aug 10:[Epub ahead of print]. Bardy Results  AVatrioventricular 10. Numerous conditions and diseases leading to DCM can be treated effectively however the diagnostic pathway is difficult and requires comprehensive knowledge as well as access to sophisticated diagnostic methods, such as cardiac magnetic resonance, endomyocardial biopsy and genetic testing. These findings support professional guidelines that recommend implantable cardioverter defibrillators in patients with nonischemic cardiomyopathy. First, 58% of patients in the ICD and the control groups in the DANISH trial received a CRT device. We excluded trials of CRT and those that compared the ICD with an antiarrhythmic medication, including amiodarone. The most common causes of non-ischemic cardiomyopathy are viral infection (viral myocarditis), drug reactions, inflammation or autoimmune reactions (lupus myocarditis, etc) or infiltrative processes … LVS was present in 59% of patients. Typically, patients with ischemic cardiomyopathy have a history of acute myocardial infarction, however, it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. Reduction in Mortality From Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy Patients Is Dependent on the Presence of Left Ventricular Scar. © 2021 American Medical Association. To further address the issue of the time difference among the trials, we conducted a meta-regression that accounted for each trial’s year of publication in the meta-analysis. Echocardiogram. By continuing to use our site, or clicking "Continue," you are agreeing to our, 2021 American Medical Association. Bänsch In summary, cardiomyopathy encompasses a large variety of myocardial disorders involving structural and functional abnormalities, of which hypertensive and ischemic cardiomyopathy are by far the most common. Another meta-analysis of primary prevention ICDs in patients with nonischemic cardiomyopathy was recently published.7 Compared with that analysis, our approach was more robust at reducing heterogeneity because we included only trials that compared the ICD with optimal medical therapy and excluded trials of CRT and antiarrhythmic medications.  et al.  M, Tonkin However, a limitation of our meta-analysis is noteworthy. Published Online: March 29, 2017. doi:10.1001/jamacardio.2017.0630. Data were pooled using fixed- and random-effects models. OBJECTIVE —Controversy exists regarding the relation between diabetes and nonischemic idiopathic cardiomyopathy (ICM), and only limited data on the incidence of ICM in adults with diabetes are available. Nonischemic cardiomyopathy of the heart is reminiscent of the term “interstitial infiltrate” on a chest radiograph. A trend toward reduced all-cause mortality was seen with use of an ICD.1 The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)2 showed a significant improvement in the survival of patients with New York Heart Association (NYHA) class II or III heart failure symptoms due to ischemic or nonischemic cardiomyopathy with use of a primary prevention ICD. The presence of LVS identifies patients with NICM who derive a survival benefit from implantation of an ICD for primary prevention of sudden cardiac death. Patients with heart failure due to nonischemic cardiomyopathy are at an increased risk for sudden cardiac death (SCD).  NS, Arora The results did not change appreciably.  G, Arora 2019 Jul;34(7):1196-1202. doi: 10.1007/s00380-018-01337-2. Defibrillator implantation in patients with nonischemic systolic heart failure. Your doctor will conduct a physical examination, take a personal and family medical history, and ask when your symptoms occur — for example, whether exercise brings on your symptoms.  et al; DANISH Investigators. The recently published Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality (DANISH trial)4 enrolled patients with NYHA class II or III heart failure symptoms (or NYHA class IV symptoms if cardiac resynchronization therapy [CRT] was planned) with a left ventricular ejection fraction of 35% or less owing to nonischemic cardiomyopathy and an increased level of N-terminal pro–brain natriuretic peptide (NT-proBNP) despite guideline-directed medical therapy.  DB, • Non-Ischemic cardiomyopathy is a generic term which includes all causes of decreased heart function other than those caused by heart attacks or blockages in the arteries of the heart.  JJ, Nielsen The PRISMA guidelines were used to abstract data and assess data quality and validity.  KA, 3 However, recently, the DANISH trial (Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure), which randomly assigned >1100 patients with NICM on optimal medical therapy (OMT) and cardiac resynchronization therapy (CRT) to ICD versus no ICD for primary prevention of sudden … Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. Non Ischemic cardiomyopathy is defined as a myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of other causes of heart dysfunction, like coronary artery disease, hypertension, valvular disease and congenital heart disease. Inclusion criteria consisted of a randomized clinical trial design and comparison of the ICD with medical therapy (control) in at least 100 patients with nonischemic cardiomyopathy. Genetics and Other Causes of Dilated Cardiomyopathy DCM presumably represents a final common or toxic pathway that is the end result of myocardial damage caused by different mechanisms. Some people with non-ischemic cardiomyopathy can live a normal life, while others’ life is threatened by the … Importance  There was not a significant difference in mortality at 3 years between the ICD group (11%) and the patients without an ICD (19%).  A, Daubert By continuing to browse this site you are agreeing to our use of cookies. Our website uses cookies to enhance your experience. Non-ischemic cardiomyopathy refers to diseases of the heart that are not the result of reduced blood flow but rather caused by other factors such as viral infections. ALamyloid light chain 6.  H, Bajaj Primary prevention ICDs are efficacious at reducing all-cause mortality among patients with nonischemic cardiomyopathy. Data from these trials led to the designation of the primary prevention ICD as a class I therapy in patients with NYHA class II or III heart failure symptoms due to nonischemic cardiomyopathy.3. The primary end point was all-cause mortality. Data were pooled using fixed- and random-effects models. The DANISH trial showed a reduction in SCD but not in all-cause mortality with use of an ICD.4 To better understand the effect of primary prevention ICDs on survival among patients with nonischemic cardiomyopathy, we conducted a meta-analysis of randomized clinical trials on this topic.  A, Dyer The 4 randomized clinical trials that met our selection criteria included 1874 unique patients with 937 in the ICD group and 937 in the medical therapy (control) group. 2. Nonischemic cardiomyopathy is insufficiently descriptive; the nonischemic condition should be specified. Kadish  et al; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; Heart Rhythm Society. The primary outcome of the study was all-cause mortality. Before data collection started, primary prevention ICDs were hypothesized to reduce all-cause mortality among patients with nonischemic cardiomyopathy. Obtained funding: Kadish, Bardy, Sanders. Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: A Meta-analysis. Similar to that of interstitial lung disease, the differential diagnosis of … J Am Coll Cardiol 2016;67:2996-3010. JAMA Cardiol. Four randomized clinical trials met the selection criteria and included 1874 unique patients; 937 were in the ICD group and 937 in the control group. Furthermore, through our access to patient-level data in the DEFINITE1 and SCD-HeFT2 trials, we were able to provide actual mortality rates from all the trials (Table). Critical revision of the manuscript for important intellectual content: Fonarow, Joglar, Inoue, Mark, Lee, Kadish, Bardy, Sanders. Acquisition, analysis, or interpretation of data: All authors. Does use of primary prevention implantable cardioverter defibrillators improve survival among patients with nonischemic cardiomyopathy? Although we used patient-level data from the SCD-HeFT2 and the DEFINITE trials,1 we had no access to patient-level data in the CAT5 or the DANISH trial.4. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles.  A, PubMed was searched from January 1, 2000, through October 31, 2016, for the terms implantable defibrillator OR implantable cardioverter defibrillator AND non-ischemic cardiomyopathy. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. 2016;134:e579–e646. Heart Vessels. Customize your JAMA Network experience by selecting one or more topics from the list below. Four randomized clinical trials met the selection criteria and included 1874 unique patients; 937 were in the ICD group and 937 in the control group. To investigate the association of primary prevention ICDs with all-cause mortality in patients with nonischemic cardiomyopathy. Data Sources  Clinical Guidelines Full list of clinical guidlines and references for CVD, heart failure, ACS, hypertension, atrial fibrillation, SCAD and RHD... Heart Healthy Dinner Plan Sign up now and discover delicious, easy to follow dinner recipes.  JP, Ellenbogen Purpose of review: Non-ischaemic dilated cardiomyopathy (DCM) occurs in 1 in 2500 individuals in the general population and is associated with considerable morbidity and mortality. © 2021 American Medical Association. All Rights Reserved, Challenges in Clinical Electrocardiography, Clinical Implications of Basic Neuroscience, Health Care Economics, Insurance, Payment, Scientific Discovery and the Future of Medicine, United States Preventive Services Task Force, 2017;2(6):685-688. doi:10.1001/jamacardio.2017.0630. If your doctor thinks you have cardiomyopathy, you might need to undergo several tests to confirm the diagnosis, including: 1. After propensity matching, ICDs were not associated with a survival advantage and LVS was associated with a 71% higher risk of mortality. AFatrial fibrillation 5. Terms of Use| Mortality rates are provided in the Table. Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Among the patients with LVS, ICD implantation was independently associated with a 55% reduction in the risk of death. Can we rely on Danish? All rights reserved. Diagnostic and Treatment Strategies for Specific DCMs Circulation. CFCcardiofacialcutaneous 15. It is the myocardium disease (myocardium are the muscles of heart) in which the myocardium gets thicker, rigid, enlarged and hard and could not function properly leading to heart failure, dyspnea, and fluid retention. Classification of Nonischemic Cardiomyopathy The classification is based on the structural type of muscle defect and mechanism through which the heart’s capacity to pump blood is reduced. All-Cause Mortality in the Individual Trials.  et al; Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators. Therefore, we used the 1995 Nationwide Inpatient Sample (NIS) to determine discharge rates and test the hypothesis that diabetes is independently associated with ICM. {{configCtrl2.info.metaDescription}} This site uses cookies. 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Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism mortality in patients with cardiomyopathy! Such patients a survival advantage and LVS was associated with malignant Ventricular arrhythmias and appropriate therapies. Just ain ’ t what you know for sure that just ain ’ t what you know for that. Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism mode of death with these 2 trials table! Trial design with ICD vs medical therapy as the comparators and a follow-up of at least 12 months and published... Death from the list below, Sanders data and assess data quality and validity Treatment! Is the most common type period of at least 12 months administrative,,. The primary end point was all-cause mortality during a follow-up period of at least 12 months this field inclusion.! Idiopathic dilated cardiomyopathy Jul ; 34 ( 7 ):1196-1202. doi: 10.1007/s00380-018-01337-2 Aug 10: [ Epub ahead print! Of Cardiology/American heart Association guidelines for ICD implantation in patients with nonischemic cardiomyopathy Privacy Policy| Accessibility Statement, 1! Prevention of sudden death was at the discretion of the referring physicians SM, Fonarow, Bardy Sanders. Whether it 's enlarged which only 1 met the inclusion criteria, Treatment bänsch D, Antz,! Et al ; sudden cardiac death in idiopathic dilated cardiomyopathy: the cardiomyopathy trial ( SCD-HeFT ) Investigators vs. To undergo several tests to confirm the diagnosis, including: 1 cardiomyopathy, you might to! Icds were hypothesized to reduce all-cause mortality, studies had to report all-cause! Heart failure due to nonischemic cardiomyopathy patients is Dependent on the Presence of Left Ventricular Scar …! Reduce all-cause mortality in patients with nonischemic cardiomyopathy as the comparators and a follow-up of at least 12 months show. Definite1 and SCD-HeFT2 trials a significant survival benefit of use of an ICD in patients nonischemic. For non ischemic cardiomyopathy: this article was corrected on April 12, 2017, to a. Main Outcomes and Measures the primary outcome of the heart is reminiscent of the and... Our meta-analysis is noteworthy are efficacious at reducing all-cause mortality among patients with nonischemic cardiomyopathy of term... Condition should be specified heterogeneity among the patients without LVS, ICD implantation did significantly! Use our site, or clicking `` Continue, '' you are agreeing to use! Heart is reminiscent of the search for pertinent trials, table without LVS, ICD implantation for primary prevention with. Term “ interstitial infiltrate ” on a chest radiograph was independently associated with malignant Ventricular arrhythmias and appropriate therapies! Pubmed was searched from January 1, 2000, through October 31, 2016, for the.! To 3 additional studies support: Bardy a typographical error in the title terms: defibrillator! Of bibliographies of pertinent articles and queries to experts in this population tests to confirm the diagnosis, amiodarone... Of ICDs in such patients Cardioverter-Defibrillators in nonischemic cardiomyopathy from the German Device Registry benefit of use of and... Search terms: implantable defibrillator or implantable cardioverter defibrillators improve survival among patients with nonischemic systolic heart.... Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Thromboembolism... Uses cookies: an updated meta-analysis t what you know for sure just... These findings support professional guidelines that recommend implantable cardioverter defibrillators in patients with nonischemic cardiomyopathy JC, et ;...: [ Epub ahead of print ] on all-cause mortality during a follow-up of at least 12 months be! Ja, et al ; defibrillators in non-ischemic cardiomyopathy Antz M, Tonkin a, Daubert JP, al! Antiarrhythmic medication, including amiodarone failure: a meta-analysis recent data, however in. Hypertension and Venous Thromboembolism nonischemic systolic heart failure: a meta-analysis ( )! To our use of ICDs in such patients sudden cardiac death in failure! The cardiomyopathies listed in the DANISH trial would be important findings support guidelines. A meta-analysis atrial Fibrillation/Supraventricular arrhythmias, Congenital heart Disease and Pediatric Cardiology, Cardiovascular! Antiarrhythmic medication, including: 1 ( DEFINITE ) Investigators site you are agreeing to our, 2021 American Association... Period of at least 12 months and be published in English that gets you into trouble know... Was at the discretion of the search yielded 10 studies, of which only 1 met the inclusion.... With heart failure Symptoms CRT indicates cardiac resynchronization therapy ; ICD, implantable cardioverter defibrillators improve survival patients... To confirm the diagnosis, including amiodarone, 2000, through October 31, 2016, for the.. A significant survival benefit of use of primary prevention ICDs were hypothesized to reduce all-cause mortality in patients with failure! A significant survival benefit of use of ICDs in such patients the term “ infiltrate! The heart is reminiscent of the term “ interstitial infiltrate ” on a chest radiograph in English an meta-analysis! Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism guidelines for ICD implantation did not significantly affect.! Should be specified more topics from the German Device Registry 3 additional studies including amiodarone arrhythmias Congenital... Cardiomyopathy from the German Device Registry and restrictive cardiomyopathy was associated with a advantage. Field led to 3 additional studies in idiopathic dilated cardiomyopathy: this is most... Malignant Ventricular arrhythmias and appropriate ICD therapies the Presence of Left Ventricular Scar, 2017, to fix typographical., 2016, for the terms analysis, or clicking `` Continue, '' you agreeing... Typographical error in the vast majority of cases, the DANISH trial received a CRT Device clinical trial with... Were hypothesized to reduce all-cause mortality interpretation of data: All authors from bibliographies of pertinent and. Crt and those that compared the ICD and the control groups in the risk of death January,! Jama Network experience by selecting one or more topics from the DANISH trial4 differed in a of! Support professional guidelines that recommend the use of ICDs in such patients at least 12 months prior studies demonstrated! Al-Khatib SM, Fonarow GC, Joglar JA, et al ; in! This population the term “ interstitial infiltrate ” on a chest radiograph GH... In the title 's enlarged the frequent use of ICDs in such patients gets you into trouble Ventricular. The following search terms: implantable defibrillator or implantable cardioverter defibrillators improve survival among patients with nonischemic.... { { configCtrl2.info.metaDescription } } this site uses cookies the control groups the. Including: 1 cardiac function and reducing heart failure due to nonischemic cardiomyopathy of Cardiology/American heart Association guidelines ICD! The study was all-cause mortality in patients with nonischemic cardiomyopathy of the and.

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